miRZip anti-sense microRNAs are stably expressed RNAi hairpins that produce mature anti-microRNAs. These miRZips antagonize its endogenous microRNA target and inhibit its function.

The miRZip construct produces high levels of anti-sense small RNAs that target a specific microRNA. Upon binding, the miRZip provides a more stable template for the microRNA to bind to and sequestering it from participating in RISC-associated target mRNA translation inhibition.